Prevalence of local immune response against oral infection in a Drosophila/Pseudomonas infection model.

ABSTRACT: Pathogens have developed multiple strategies that allow them to exploit host resources and resist the immune response. To study how Drosophila flies deal with infectious diseases in a natural context, we investigated the interactions between Drosophila and a newly identified entomopathogen, Pseudomonas entomophila. Flies orally infected with P. entomophila rapidly succumb despite the induction of both local and systemic immune responses, indicating that this bacterium has developed specific strategies to escape the fly immune response. Using a combined genetic approach on both host and pathogen, we showed that P. entomophila virulence is multi-factorial with a clear differentiation between factors that trigger the immune response and those that promote pathogenicity. We demonstrate that Ap

SUBMITTER: Liehl P 

PROVIDER: S-EPMC1475658 | biostudies-literature | 2006 Jun

REPOSITORIES: biostudies-literature