Catalytic ester-amide exchange using group (IV) metal alkoxide-activator complexes.

ABSTRACT: A process for preparation of amides from unactivated esters and amines has been developed using a catalytic system comprised of group (IV) metal alkoxides in conjunction with additives including 1-hydroxy-7-azabenzotriazole (HOAt). In general, ester-amide exchange proceeds using a variety of structurally diverse esters and amines without azeotropic reflux to remove the alcohol byproduct. Initial mechanistic studies on the Zr(Ot-Bu)4-HOAt system revealed that the active catalyst is a novel, dimeric zirconium complex as determined by X-ray crystallography.

SUBMITTER: Han C 

PROVIDER: S-EPMC1475744 | biostudies-literature | 2005 Jul

REPOSITORIES: biostudies-literature