Effectiveness of discontinuing antibiotic treatment after three days versus eight days in mild to moderate-severe community acquired pneumonia: randomised, double blind study.

ABSTRACT:

Objective

To compare the effectiveness of discontinuing treatment with amoxicillin after three days or eight days in adults admitted to hospital with mild to moderate-severe community acquired pneumonia who substantially improved after an initial three days' treatment.

Design

Randomised, double blind, placebo controlled non-inferiority trial.

Setting

Nine secondary and tertiary care hospitals in the Netherlands.

Participants

Adults with mild to moderate-severe community acquired pneumonia (pneumonia severity index score < or = 110).

Interventions

Patients who had substantially improved after three days' treatment with intravenous amoxicillin were randomly assigned to oral amoxicillin (n = 63) or placebo (n = 56) three times daily for five days.

Main o

SUBMITTER: el Moussaoui R 

PROVIDER: S-EPMC1479094 | biostudies-literature | 2006 Jun

REPOSITORIES: biostudies-literature