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Biological, biochemical, and molecular characterization of a new clinical Trichophyton rubrum isolate resistant to terbinafine.

ABSTRACT: We have characterized a new clinical strain of Trichophyton rubrum highly resistant to terbinafine but exhibiting normal susceptibility to drugs with other mechanisms of action. Resistance to terbinafine in this strain is caused by a missense mutation in the squalene epoxidase gene leading to the amino acid substitution F397L.

SUBMITTER: Osborne CS 

PROVIDER: S-EPMC1479141 | biostudies-literature | 2006 Jun

REPOSITORIES: biostudies-literature

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Biological, biochemical, and molecular characterization of a new clinical Trichophyton rubrum isolate resistant to terbinafine.

Osborne Colin S CS   Leitner Ingrid I   Hofbauer Bettina B   Fielding Ceri A CA   Favre Bertrand B   Ryder Neil S NS  

Antimicrobial agents and chemotherapy 20060601 6

We have characterized a new clinical strain of Trichophyton rubrum highly resistant to terbinafine but exhibiting normal susceptibility to drugs with other mechanisms of action. Resistance to terbinafine in this strain is caused by a missense mutation in the squalene epoxidase gene leading to the amino acid substitution F397L. ...[more]

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