Biological, biochemical, and molecular characterization of a new clinical Trichophyton rubrum isolate resistant to terbinafine.

ABSTRACT: We have characterized a new clinical strain of Trichophyton rubrum highly resistant to terbinafine but exhibiting normal susceptibility to drugs with other mechanisms of action. Resistance to terbinafine in this strain is caused by a missense mutation in the squalene epoxidase gene leading to the amino acid substitution F397L.

SUBMITTER: Osborne CS 

PROVIDER: S-EPMC1479141 | biostudies-literature | 2006 Jun

REPOSITORIES: biostudies-literature