Differences in gene expression between the classical and El Tor biotypes of Vibrio cholerae O1.

ABSTRACT: Differences in whole-genome expression patterns between the classical and El Tor biotypes of Vibrio cholerae O1 were determined under conditions that induce virulence gene expression in the classical biotype. A total of 524 genes (13.5% of the genome) were found to be differentially expressed in the two biotypes. The expression of genes encoding proteins required for biofilm formation, chemotaxis, and transport of amino acids, peptides, and iron was higher in the El Tor biotype. These gene expression differences may contribute to the enhanced survival capacity of the El Tor biotype in environmental reservoirs. The expression of genes encoding virulence factors was higher in the classical than in the El Tor biotype. In addition, the vieSAB genes, which were originally identified as regulato

SUBMITTER: Beyhan S 

PROVIDER: S-EPMC1479229 | biostudies-literature | 2006 Jun

REPOSITORIES: biostudies-literature