Isolation of a human monoclonal antibody with strong neutralizing activity against diphtheria toxin.

ABSTRACT: We isolated a human monoclonal antibody against diphtheria toxin (DT). It bound to fragment B with a binding activity (Kd) of 3.01 nM. The neutralizing activity assayed by the rabbit skin test was estimated to be 73,600 IU/g. This could be used as a therapeutic drug against DT in place of the traditional equine sera.

SUBMITTER: Kakita M 

PROVIDER: S-EPMC1479265 | biostudies-literature | 2006 Jun

REPOSITORIES: biostudies-literature