Analyses of Five gallinacin genes and the Salmonella enterica serovar Enteritidis response in poultry.

ABSTRACT: Gallinacins in poultry are functional equivalents of mammalian beta-defensins, which constitute an integral component of the innate immune system. Salmonella enterica serovar Enteritidis is a gram-negative bacterium that negatively affects both human and animal health. To analyze the association of genetic variations of the gallinacin genes with the phenotypic response to S. enterica serovar Enteritidis, an F1 population of chickens was created by crossing four outbred broiler sires to dams of two highly inbred lines. The F1 chicks were evaluated for bacterial colonization after pathogenic S. enterica serovar Enteritidis inoculation and for circulating antibody levels after inoculation with S. enterica serovar Enteritidis bacterin vaccine. Five candidate genes were studied, including galli

SUBMITTER: Hasenstein JR 

PROVIDER: S-EPMC1479296 | biostudies-literature | 2006 Jun

REPOSITORIES: biostudies-literature