Constitutive differences in gene expression profiles parallel genetic patterns of susceptibility to tuberculosis in mice.

ABSTRACT: Interstitial lung macrophages from tuberculosis-susceptible I/St and tuberculosis-resistant A/Sn mice demonstrated significant constitutive differences in gene expression levels, whereas in vitro infection of these cells with Mycobacterium tuberculosis had only a modulatory impact on gene expression. We conclude that intrinsic gene expression profiles are an important determinant of tuberculosis pathogenesis in mice.

SUBMITTER: Orlova MO 

PROVIDER: S-EPMC1479297 | biostudies-literature | 2006 Jun

REPOSITORIES: biostudies-literature