Physiogenomic analysis of weight loss induced by dietary carbohydrate restriction.

ABSTRACT:

Background

Diets that restrict carbohydrate (CHO) have proven to be a successful dietary treatment of obesity for many people, but the degree of weight loss varies across individuals. The extent to which genetic factors associate with the magnitude of weight loss induced by CHO restriction is unknown. We examined associations among polymorphisms in candidate genes and weight loss in order to understand the physiological factors influencing body weight responses to CHO restriction.

Methods

We screened for genetic associations with weight loss in 86 healthy adults who were instructed to restrict CHO to a level that induced a small level of ketosis (CHO approximately 10% of total energy). A total of 27 single nucleotide polymorphisms (SNPs) were selected from 15 candidate genes

SUBMITTER: Ruano G 

PROVIDER: S-EPMC1479825 | biostudies-literature | 2006 May

REPOSITORIES: biostudies-literature