Biological efficacy of low versus medium dose aspirin after coronary surgery: results from a randomized trial [NCT00262275].

ABSTRACT:

Background

The beneficial effect of aspirin after coronary surgery is established; however, a recent study reported the inability of low doses (100 mg) to inhibit postoperative platelet function. We conducted a double-blind randomised trial to establish the efficacy of low dose aspirin and to compare it against medium dose aspirin.

Methods

Patients undergoing coronary surgery were invited to participate and consenting patients were randomised to 100 mg or 325 mg of aspirin daily for 5 days. Our primary outcome was the difference in platelet aggregation (day 5 - baseline) using 1 microg/ml of collagen. Secondary outcomes were differences in EC50 of collagen, ADP and epinephrine (assessed using the technique of Born).

Results

From September 2002 to April 2004, 72 patien

SUBMITTER: Lim E 

PROVIDER: S-EPMC1479833 | biostudies-literature | 2006 May

REPOSITORIES: biostudies-literature