Synthetic studies on the bryostatins: synthetic routes to analogues containing the tricyclic macrolactone core.

ABSTRACT: [reaction: see text]. Synthesis of the first of a projected series of bryostatin analogues has been accomplished in 26 steps and 2.2% overall yield. In this letter, we detail two approaches to the structural core of these tricyclic macrolactone bryostatin analogues. The key features of the route include BITIP-catalyzed asymmetric allylation reactions and Mukaiyama aldol reactions, a chelation-controlled allylation, pyran annulation reactions, and macrolactonization.

SUBMITTER: Keck GE 

PROVIDER: S-EPMC1480407 | biostudies-literature | 2005 May

REPOSITORIES: biostudies-literature