Causal inference of regulator-target pairs by gene mapping of expression phenotypes.

ABSTRACT:

Background

Correlations between polymorphic markers and observed phenotypes provide the basis for mapping traits in quantitative genetics. When the phenotype is gene expression, then loci involved in regulatory control can theoretically be implicated. Recent efforts to construct gene regulatory networks from genotype and gene expression data have shown that biologically relevant networks can be achieved from an integrative approach. In this paper, we consider the problem of identifying individual pairs of genes in a direct or indirect, causal, trans-acting relationship.

Results

Inspired by epistatic models of multi-locus quantitative trait (QTL) mapping, we propose a unified model of expression and genotype to identify quantitative trait genes (QTG) by extending the conventi

SUBMITTER: Kulp DC 

PROVIDER: S-EPMC1481560 | biostudies-literature | 2006 May

REPOSITORIES: biostudies-literature