Markers of exacerbation severity in chronic obstructive pulmonary disease.

ABSTRACT:

Background

Patients with chronic obstructive pulmonary disease (COPD) can experience 'exacerbations' of their conditions. An exacerbation is an event defined in terms of subjective descriptors or symptoms, namely dyspnoea, cough and sputum that worsen sufficiently to warrant a change in medical management. There is a need for reliable markers that reflect the pathological mechanisms that underlie exacerbation severity and that can be used as a surrogate to assess treatment effects in clinical studies. Little is known as to how existing study variables and suggested markers change in both the stable and exacerbation phases of COPD. In an attempt to find the best surrogates for exacerbations, we have reviewed the literature to identify which of these markers change in a consistent ma

SUBMITTER: Franciosi LG 

PROVIDER: S-EPMC1481583 | biostudies-literature | 2006 May

REPOSITORIES: biostudies-literature