Compensation by tumor suppressor genes during retinal development in mice and humans.

ABSTRACT:

Background

The RB1 gene was the first tumor suppressor gene cloned from humans by studying genetic lesions in families with retinoblastoma. Children who inherit one defective copy of the RB1 gene have an increased susceptibility to retinoblastoma. Several years after the identification of the human RB1 gene, a targeted deletion of Rb was generated in mice. Mice with one defective copy of the Rb gene do not develop retinoblastoma. In this manuscript, we explore the different roles of the Rb family in human and mouse retinal development in order to better understand the species-specific difference in retinoblastoma susceptibility.

Results

We found that the Rb family of proteins (Rb, p107 and p130) are expressed in a dynamic manner during mouse retinal development. The primary

SUBMITTER: Donovan SL 

PROVIDER: S-EPMC1481602 | biostudies-literature | 2006 May

REPOSITORIES: biostudies-literature