An integrated approach to the prediction of domain-domain interactions.

ABSTRACT:

Background

The development of high-throughput technologies has produced several large scale protein interaction data sets for multiple species, and significant efforts have been made to analyze the data sets in order to understand protein activities. Considering that the basic units of protein interactions are domain interactions, it is crucial to understand protein interactions at the level of the domains. The availability of many diverse biological data sets provides an opportunity to discover the underlying domain interactions within protein interactions through an integration of these biological data sets.

Results

We combine protein interaction data sets from multiple species, molecular sequences, and gene ontology to construct a set of high-confidence domain-domain inte

SUBMITTER: Lee H 

PROVIDER: S-EPMC1481624 | biostudies-literature | 2006 May

REPOSITORIES: biostudies-literature