Genome wide prediction of protein function via a generic knowledge discovery approach based on evidence integration.

ABSTRACT:

Background

The automation of many common molecular biology techniques has resulted in the accumulation of vast quantities of experimental data. One of the major challenges now facing researchers is how to process this data to yield useful information about a biological system (e.g. knowledge of genes and their products, and the biological roles of proteins, their molecular functions, localizations and interaction networks). We present a technique called Global Mapping of Unknown Proteins (GMUP) which uses the Gene Ontology Index to relate diverse sources of experimental data by creation of an abstraction layer of evidence data. This abstraction layer is used as input to a neural network which, once trained, can be used to predict function from the evidence data of unannotated prote

SUBMITTER: Xiong J 

PROVIDER: S-EPMC1481625 | biostudies-literature | 2006 May

REPOSITORIES: biostudies-literature