Experimental and computational probes of the space in a self-assembled capsule.

ABSTRACT: Self-assembled capsules are hosts that recognize and surround smaller molecule guests of appropriate size, shape, and chemical surfaces. The space available inside is a cage of fixed solvent molecules, many of which are aromatic. These aromatics provide anisotropic shielding to guests, and a map of induced magnetic shielding for the inner space can be obtained through nucleus-independent chemical shift calculations. Experimental values of the magnetic environment can be determined by NMR spectra of the guests inside. We describe here the environment in a cylindrical capsule with tapered ends. A series of terminal acetylenes -- the narrowest of organic structures -- was synthesized and used to probe the magnetic shielding of the capsule's ends. Their NMR spectra showed that the acetylenic h

SUBMITTER: Ajami D 

PROVIDER: S-EPMC1482543 | biostudies-literature | 2006 Jun

REPOSITORIES: biostudies-literature