Bovine CD2-/NKp46+ cells are fully functional natural killer cells with a high activation status.

ABSTRACT:

Background

Natural killer (NK) cells in the cow have been elusive due to the lack of specific NK cell markers, and various criteria including a CD3-/CD2+ phenotype have been used to identify such cells. The recent characterization of the NK-specific NKp46 receptor has allowed a more precise definition of bovine NK cells. NK cells are known as a heterogeneous cell group, and we here report the first functional study of bovine NK cell subsets, based on the expression of CD2.

Results

Bovine CD2- NK cells, a minor subset in blood, proliferated more rapidly in the presence of IL-2, dominating the cultures after a few days. Grown separately with IL-2, CD2- and CD2+ NK cell subsets did not change CD2 expression for at least two weeks. In blood, CD2- NK cells showed a higher express

SUBMITTER: Boysen P 

PROVIDER: S-EPMC1482717 | biostudies-literature | 2006 Apr

REPOSITORIES: biostudies-literature