Characterizing disease states from topological properties of transcriptional regulatory networks.

ABSTRACT:

Background

High throughput gene expression experiments yield large amounts of data that can augment our understanding of disease processes, in addition to classifying samples. Here we present new paradigms of data Separation based on construction of transcriptional regulatory networks for normal and abnormal cells using sequence predictions, literature based data and gene expression studies. We analyzed expression datasets from a number of diseased and normal cells, including different types of acute leukemia, and breast cancer with variable clinical outcome.

Results

We constructed sample-specific regulatory networks to identify links between transcription factors (TFs) and regulated genes that differentiate between healthy and diseased states. This approach carries the adva

SUBMITTER: Tuck DP 

PROVIDER: S-EPMC1482723 | biostudies-literature | 2006 May

REPOSITORIES: biostudies-literature