Dynamic protein domains: identification, interdependence, and stability.

ABSTRACT: Existing methods of domain identification in proteins usually provide no information about the degree of domain independence and stability. However, this information is vital for many areas of protein research. The recently developed hierarchical clustering of correlation patterns (HCCP) technique provides machine-based domain identification in a computationally simple and physically consistent way. Here we present the modification of this technique, which not only allows determination of the most plausible number of dynamic domains but also makes it possible to estimate the degree of their independence (the extent of correlated motion) and stability (the range of environmental conditions, where domains remain intact). With this technique we provided domain assignments and calculated intra

SUBMITTER: Yesylevskyy SO 

PROVIDER: S-EPMC1483087 | biostudies-literature | 2006 Jul

REPOSITORIES: biostudies-literature