Germline polymorphisms in SIPA1 are associated with metastasis and other indicators of poor prognosis in breast cancer.

ABSTRACT:

Introduction

There is growing evidence that heritable genetic variation modulates metastatic efficiency. Our previous work using a mouse mammary tumor model has shown that metastatic efficiency is modulated by the GTPase-activating protein encoded by Sipa1 ('signal-induced proliferation-associated gene 1'). The aim of this study was to determine whether single nucleotide polymorphisms (SNPs) within the human SIPA1 gene are associated with metastasis and other disease characteristics in breast cancer.

Method

The study population (n = 300) consisted of randomly selected non-Hispanic Caucasian breast cancer patients identified from a larger population-based series. Genomic DNA was extracted from peripheral leukocytes. Three previously described SNPs within SIPA1 (one within the

SUBMITTER: Crawford NP 

PROVIDER: S-EPMC1483843 | biostudies-literature | 2006

REPOSITORIES: biostudies-literature