An informatics model for tissue banks--lessons learned from the Cooperative Prostate Cancer Tissue Resource.

ABSTRACT:

Background

Advances in molecular biology and growing requirements from biomarker validation studies have generated a need for tissue banks to provide quality-controlled tissue samples with standardized clinical annotation. The NCI Cooperative Prostate Cancer Tissue Resource (CPCTR) is a distributed tissue bank that comprises four academic centers and provides thousands of clinically annotated prostate cancer specimens to researchers. Here we describe the CPCTR information management system architecture, common data element (CDE) development, query interfaces, data curation, and quality control.

Methods

Data managers review the medical records to collect and continuously update information for the 145 clinical, pathological and inventorial CDEs that the Resource maintains for

SUBMITTER: Patel AA 

PROVIDER: S-EPMC1484486 | biostudies-literature | 2006 May

REPOSITORIES: biostudies-literature