A meta-analysis of the association between adherence to drug therapy and mortality.

ABSTRACT:

Objective

To evaluate the relation between adherence to drug therapy, including placebo, and mortality.

Design

Meta-analysis of observational studies.

Data sources

Electronic databases, contact with investigators, and textbooks and reviews on adherence. Review methods Predefined criteria were used to select studies reporting mortality among participants with good and poor adherence to drug therapy. Data were extracted for disease, drug therapy groups, methods for measurement of adherence rate, definition for good adherence, and mortality.

Results

Data were available from 21 studies (46,847 participants), including eight studies with placebo arms (19,633 participants). Compared with poor adherence, good adherence was associated with lower mortality (odds ratio 0

SUBMITTER: Simpson SH 

PROVIDER: S-EPMC1488752 | biostudies-literature | 2006 Jul

REPOSITORIES: biostudies-literature