Validation of genomics-based prognostic tests in malignant pleural mesothelioma.

ABSTRACT:

Purpose

Malignant pleural mesothelioma (MPM) is a highly lethal neoplasm with limited pretreatment prognostication strategies. In this report, we examine the accuracy of a previously proposed prognostic test in an independent cohort of MPM patients. This test uses simple ratios of gene expression levels to provide a novel prognostication scheme.

Experimental design

Gene expression data using high-density oligonucleotide microarrays (approximately 22,000 genes) were obtained for a new cohort of human MPM tumors from patients undergoing similar treatments (n = 39). The relative expression levels for specific genes were also determined using real-time quantitative reverse transcription-PCR. We also used a subset of these tumors associated with widely divergent patient survival

SUBMITTER: Gordon GJ 

PROVIDER: S-EPMC1488818 | biostudies-literature | 2005 Jun

REPOSITORIES: biostudies-literature