Binary gene induction and protein expression in individual cells.

ABSTRACT:

Background

Eukaryotic gene transcription is believed to occur in either a binary or a graded fashion. With binary induction, a transcription activator (TA) regulates the probability with which a gene template is switched from the inactive to the active state without affecting the rate at which RNA molecules are produced from the template. With graded, also called rheostat-like, induction the gene template has continuously varying levels of transcriptional activity, and the TA regulates the rate of RNA production. Support for each of these two mechanisms arises primarily from experimental studies measuring reporter proteins in individual cells, rather than from direct measurement of induction events at the gene template.

Methods and results

In this paper, using a computationa

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC1488830 | biostudies-literature | 2006 Apr

REPOSITORIES: biostudies-literature