Association study of genetic variants of pro-inflammatory chemokine and cytokine genes in systemic lupus erythematosus.

ABSTRACT:

Background

Several lines of evidence suggest that chemokines and cytokines play an important role in the inflammatory development and progression of systemic lupus erythematosus. The aim of this study was to evaluate the relevance of functional genetic variations of RANTES, IL-8, IL-1alpha, and MCP-1 for systemic lupus erythematosus.

Methods

The study was conducted on 500 SLE patients and 481 ethnically matched healthy controls. Genotyping of polymorphisms in the RANTES, IL-8, IL-1alpha, and MCP-1 genes were performed using a real-time polymerase chain reaction (PCR) system with pre-developed TaqMan allelic discrimination assay.

Results

No significant differences between SLE patients and healthy controls were observed when comparing genotype, allele or haplotype frequ

SUBMITTER: Sanchez E 

PROVIDER: S-EPMC1488833 | biostudies-literature | 2006 May

REPOSITORIES: biostudies-literature