Network motifs: structure does not determine function.

ABSTRACT:

Background

A number of publications have recently examined the occurrence and properties of the feed-forward motif in a variety of networks, including those that are of interest in genome biology, such as gene networks. The present work looks in some detail at the dynamics of the bi-fan motif, using systems of ordinary differential equations to model the populations of transcription factors, mRNA and protein, with the aim of extending our understanding of what appear to be important building blocks of gene network structure.

Results

We develop an ordinary differential equation model of the bi-fan motif and analyse variants of the motif corresponding to its behaviour under various conditions. In particular, we examine the effects of different steady and pulsed inputs to five

SUBMITTER: Ingram PJ 

PROVIDER: S-EPMC1488845 | biostudies-literature | 2006 May

REPOSITORIES: biostudies-literature