Single nucleotide polymorphisms of the APC gene and colorectal cancer risk: a case-control study in Taiwan.

ABSTRACT:

Background

Colorectal cancer (CRC), which has become especially prevalent in developed countries, is currently the third highest cause of cancer mortality in Taiwan. Mutation of the adenomatous polyposis coli (APC) gene, a tumour suppressor, is thought to be an early event in colorectal tumourigenesis. To date, however, no large-scale screening for APC gene variants in Chinese subjects has been performed. The present study was undertaken to identify APC gene variants that are significantly associated with the occurrence of CRC in Taiwanese subjects.

Methods

In order to compare the genotype distribution of variant sites, the full-length APC genes of 74 healthy individuals and 80 CRC patients were sequenced.

Results

Among the 154 Taiwanese subjects examined in this stud

SUBMITTER: Chen SP 

PROVIDER: S-EPMC1488868 | biostudies-literature | 2006 Mar

REPOSITORIES: biostudies-literature