Linkage disequilibrium blocks, haplotype structure, and htSNPs of human CYP7A1 gene.

ABSTRACT:

Background

Cholesterol 7-alpha-hydroxylase (CYP7A1) is the rate limiting enzyme for converting cholesterol into bile acids. Genetic variations in the CYP7A1 gene have been associated with metabolic disorders of cholesterol and bile acids, including hypercholesterolemia, hypertriglyceridemia, arteriosclerosis, and gallstone disease. Current genetic studies are focused mainly on analysis of a single nucleotide polymorphism (SNP) at A-278C in the promoter region of the CYP7A1 gene. Here we report a genetic approach for an extensive analysis on linkage disequilibrium (LD) blocks and haplotype structures of the entire CYP7A1 gene and its surrounding sequences in Africans, Caucasians, Asians, Mexican-Americans, and African-Americans.

Result

The LD patterns and haplotype blocks of

SUBMITTER: Nakamoto K 

PROVIDER: S-EPMC1488870 | biostudies-literature | 2006 May

REPOSITORIES: biostudies-literature