Artemisinin combination therapies for treatment of uncomplicated malaria in Uganda.

ABSTRACT:

Objectives

To compare the efficacy and safety of artemisinin combination therapies for the treatment of uncomplicated falciparum malaria in Uganda.

Design

Randomized single-blind controlled trial.

Setting

Tororo, Uganda, an area of high-level malaria transmission.

Participants

Children aged one to ten years with confirmed uncomplicated P. falciparum malaria.

Interventions

Amodiaquine + artesunate or artemether-lumefantrine.

Outcome measures

Risks of recurrent symptomatic malaria and recurrent parasitemia at 28 days, unadjusted and adjusted by genotyping to distinguish recrudescences and new infections.

Results

Of 408 participants enrolled, 403 with unadjusted efficacy outcomes were included in the per-protocol analysis. Both treatment regim

SUBMITTER: Bukirwa H 

PROVIDER: S-EPMC1488893 | biostudies-literature | 2006 May

REPOSITORIES: biostudies-literature