Acute effect of folic acid, betaine, and serine supplements on flow-mediated dilation after methionine loading: a randomized trial.

ABSTRACT:

Objectives

We investigated whether reducing post-methionine homocysteine concentrations via various treatments other than folic acid affects vascular function, as measured through flow-mediated dilation (FMD) of the brachial artery. High fasting and post-methionine homocysteine concentrations are associated with cardiovascular disease risk, but homocysteine might be a surrogate marker for low folate status.

Design

This was a randomized, placebo-controlled, double-blind, crossover study.

Setting

The study took place at Wageningen University in Wageningen in the Netherlands.

Participants

Participants were 39 apparently healthy men and women, aged 50-70 y.

Interventions

Participants ingested 10 mg of folic acid, 3 g of betaine, 5 g of serine, and placebo to

SUBMITTER: Olthof MR 

PROVIDER: S-EPMC1488894 | biostudies-literature | 2006 May

REPOSITORIES: biostudies-literature