Diagnosis of first case of Balamuthia amoebic encephalitis in Portugal by immunofluorescence and PCR.

ABSTRACT: We report here the first Portuguese case of acute fatal granulomatous encephalitis attributed to Balamuthia mandrillaris, initially thought to be a brain tumor, which had a progressive and fatal outcome. Balamuthia mandrillaris is a free-living amoeba recognized as an uncommon agent of granulomatous encephalitis. Infections have been identified in immunocompromised hosts and in immunocompetent pediatric patients. Balamuthia infections are very rare, with only two reported cases in Europe. The case presented here occurred in a previously healthy boy who died 5 weeks after the onset of the symptoms. No evidence of immunological deficiency was noted, and testing for human immunodeficiency virus antibodies was negative. The symptoms were initially thought to be the result of a tumor, but histo

SUBMITTER: Tavares M 

PROVIDER: S-EPMC1489463 | biostudies-literature | 2006 Jul

REPOSITORIES: biostudies-literature