Distinct molecular mechanisms underlying clinically relevant subtypes of breast cancer: gene expression analyses across three different platforms.

ABSTRACT:

Background

Gene expression profiling has been used to define molecular phenotypes of complex diseases such as breast cancer. The luminal A and basal-like subtypes have been repeatedly identified and validated as the two main subtypes out of a total of five molecular subtypes of breast cancer. These two are associated with distinctly different gene expression patterns and more importantly, a significant difference in clinical outcome. To further validate and more thoroughly characterize these two subtypes at the molecular level in tumors at an early stage, we report a gene expression profiling study using three different DNA microarray platforms.

Results

Expression data from 20 tumor biopsies of early stage breast carcinomas were generated on three different DNA microarray pl

SUBMITTER: Sorlie T 

PROVIDER: S-EPMC1489944 | biostudies-literature | 2006 May

REPOSITORIES: biostudies-literature