Ontology highlight
ABSTRACT:
SUBMITTER: Maillard C
PROVIDER: S-EPMC1490321 | biostudies-literature | 2005 Jan
REPOSITORIES: biostudies-literature
Maillard Catherine C Jost Maud M Rømer Maria Unni MU Brunner Nils N Houard Xavier X Lejeune Annabelle A Munaut Carine C Bajou Khalid K Melen Laurence L Dano Keld K Carmeliet Peter P Fusenig Norbert E NE Foidart Jean Michel JM Noel Agnès A
Neoplasia (New York, N.Y.) 20050101 1
Angiogenesis and tumor expansion are associated with extracellular matrix remodeling and involve various proteases such as the plasminogen (Plg)/plasminogen activator (PA) system. Recently, several experimental data have implicated the plasminogen activator inhibitor-1 (PAI-1) in tumor angiogenesis in murine systems. However, little is known about PAI-1 functions in human skin carcinoma progression. By generating immunodeficient mice (in Rag-1-/- or nude background) deleted for PAI-1 gene (PAI-1 ...[more]