Polymeric immunoglobulin receptor polymorphisms and risk of nasopharyngeal cancer.

ABSTRACT:

Background

Epstein-Barr virus (EBV) associated nasopharyngeal cancer (NPC) is an important squamous cell cancer endemic in Southeast Asia and the Far East and can be considered a multifactorial genetic disease. This research explores potential associations between nasopharyngeal epithelial EBV receptor and NPC susceptibility. To prove the hypothesis, we evaluated two candidate genes, complement receptor 2 (CR2) and polymeric immunoglobulin receptor (PIGR) by using 4 SNPs, CR2IVS2-848C-->T, PIGRIVS3-156G-->T, PIGR1093G-->A and PIGR1739C-->T, to genotype 175 cases and 317 controls, divided into Thai, Chinese and Thai-Chinese based on their respective ethnic origins.

Results

The results obtained indicated that PIGR is an NPC susceptibility gene. The risk association pertaining

SUBMITTER: Hirunsatit R 

PROVIDER: S-EPMC149362 | biostudies-literature | 2003 Jan

REPOSITORIES: biostudies-literature