Wiggle-predicting functionally flexible regions from primary sequence.

ABSTRACT: The Wiggle series are support vector machine-based predictors that identify regions of functional flexibility using only protein sequence information. Functionally flexible regions are defined as regions that can adopt different conformational states and are assumed to be necessary for bioactivity. Many advances have been made in understanding the relationship between protein sequence and structure. This work contributes to those efforts by making strides to understand the relationship between protein sequence and flexibility. A coarse-grained protein dynamic modeling approach was used to generate the dataset required for support vector machine training. We define our regions of interest based on the participation of residues in correlated large-scale fluctuations. Even with this structure

SUBMITTER: Gu J 

PROVIDER: S-EPMC1500818 | biostudies-literature | 2006 Jul

REPOSITORIES: biostudies-literature