An analysis of intra array repeats: the good, the bad and the non informative.

ABSTRACT:

Background

On most common microarray platforms many genes are represented by multiple probes. Although this is quite common no one has systematically explored the concordance between probes mapped to the same gene.

Results

Here we present an analysis of all the cases of multiple probe sets measuring the same gene on the Affymetrix U133a GeneChip and found that although in the majority of cases both measurements tend to agree there are a significant number of cases in which the two measurements differ from each other. In these cases the measurements can not be simply averaged but rather should be handled individually.

Conclusion

Our analysis allows us to provide a comprehensive list of the correlation between all pairs of probe sets that are mapped to the same gene and

SUBMITTER: Elbez Y 

PROVIDER: S-EPMC1501018 | biostudies-literature | 2006 Jun

REPOSITORIES: biostudies-literature