Differential evolutionary conservation of motif modes in the yeast protein interaction network.

ABSTRACT:

Background

The importance of a network motif (a recurring interconnected pattern of special topology which is over-represented in a biological network) lies in its position in the hierarchy between the protein molecule and the module in a protein-protein interaction network. Until now, however, the methods available have greatly restricted the scope of research. While they have focused on the analysis in the resolution of a motif topology, they have not been able to distinguish particular motifs of the same topology in a protein-protein interaction network.

Results

We have been able to assign the molecular function annotations of Gene Ontology to each protein in the protein-protein interactions of Saccharomyces cerevisiae. For various motif topologies, we have developed an a

SUBMITTER: Lee WP 

PROVIDER: S-EPMC1501022 | biostudies-literature | 2006 Apr

REPOSITORIES: biostudies-literature