Transcript AA454543 is a novel prognostic marker for hepatocellular carcinoma after curative partial hepatectomy.

ABSTRACT:

Background

We have previously reported on the cDNA microarray gene expression profiles of hepatocellular carcinomas (HCCs). Among the genes that show prognostic significance and are overexpressed in tumor compared with adjacent nontumorous liver, transcript AA454543 may have potential for practical use. Our aim is to validate the prognostic significance of transcript AA454543 by alternative research methods and in a separate group of HCC patients.

Methods and results

The data of transcript AA454543 derived from microarray analysis of 48 patients having curative partial hepatectomy (group 1) were verified by quantitative reverse transcription polymerase chain reaction (r = 0.618, P < .001). A separate sample set of HCCs obtained from 53 patients (group 2) was examined and the

SUBMITTER: Cheung ST 

PROVIDER: S-EPMC1501123 | biostudies-literature | 2005 Feb

REPOSITORIES: biostudies-literature