Altered expression of TFF-1 and CES-2 in Barrett's Esophagus and associated adenocarcinomas.

ABSTRACT: Identification of biomarkers to recognize individuals with Barrett's esophagus (BE) predisposed to develop malignancy is currently a pressing issue. We utilized gene expression profiling to compare molecular signatures of normal esophagus and stomach, BE, and adenocarcinoma (AC) to identify such potential biomarkers. Over 22,000 genes were analyzed by oligonucleotide microarrays on 38 unique RNA Unsupervised and supervised clusterings were performed on a subset of 2849 genes that varied most significantly across the specimens. Immunohistochemistry (IHC) for two of the significantly differentially expressed gene products was performed on tissue microarrays. Unsupervised clustering identified two discernable molecular BE profiles, one of which was similar to normal gastric tissue ("BE1"), an

SUBMITTER: Fox CA 

PROVIDER: S-EPMC1501154 | biostudies-literature | 2005 Apr

REPOSITORIES: biostudies-literature