Controlling interlayer diffusion to achieve sustained, multiagent delivery from layer-by-layer thin films.

ABSTRACT: We present the fabrication of conformal, hydrolytically degradable thin films capable of administering sustained, multiagent release profiles. Films are constructed one molecular layer at a time by using the layer-by-layer, directed-deposition technique; the subsequent hydrolytic surface erosion of these systems results in the release of incorporated materials in a sequence that reflects their relative positions in the film. The position of each species is determined by its ability to diffuse throughout the film architecture, and, as such, the major focus of this work is to define strategies that physically block interlayer diffusion during assembly to create multicomponent, stratified films. By using a series of radiolabeled polyelectrolytes as experimental probes, we show that covalently

SUBMITTER: Wood KC 

PROVIDER: S-EPMC1502436 | biostudies-literature | 2006 Jul

REPOSITORIES: biostudies-literature