Three rounds (1R/2R/3R) of genome duplications and the evolution of the glycolytic pathway in vertebrates.

ABSTRACT:

Background

Evolution of the deuterostome lineage was accompanied by an increase in systematic complexity especially with regard to highly specialized tissues and organs. Based on the observation of an increased number of paralogous genes in vertebrates compared with invertebrates, two entire genome duplications (2R) were proposed during the early evolution of vertebrates. Most glycolytic enzymes occur as several copies in vertebrate genomes, which are specifically expressed in certain tissues. Therefore, the glycolytic pathway is particularly suitable for testing theories of the involvement of gene/genome duplications in enzyme evolution.

Results

We assembled datasets from genomic databases of at least nine vertebrate species and at least three outgroups (one deuterostome an

SUBMITTER: Steinke D 

PROVIDER: S-EPMC1508162 | biostudies-literature | 2006 Jun

REPOSITORIES: biostudies-literature