The repertoire of protein kinases encoded in the draft version of the human genome: atypical variations and uncommon domain combinations.

ABSTRACT:

Background

Phosphorylation by protein kinases is central to cellular signal transduction. Abnormal functioning of kinases has been implicated in developmental disorders and malignancies. Their activity is regulated by second messengers and by the binding of associated domains, which are also influential in translocating the catalytic component to their substrate sites, in mediating interaction with other proteins and carrying out their biological roles.

Result

Using sensitive profile-search methods and manual analysis, the human genome has been surveyed for protein kinases. A set of 448 sequences, which show significant similarity to protein kinases and contain the critical residues essential for kinase function, have been selected for an analysis of domain combinations afte

SUBMITTER: Krupa A 

PROVIDER: S-EPMC151168 | biostudies-literature | 2002

REPOSITORIES: biostudies-literature