Heart-specific genes revealed by expressed sequence tag (EST) sampling.

ABSTRACT:

Background

Cardiovascular diseases are the primary cause of death worldwide; the identification of genes specifically expressed in the heart is thus of major biomedical interest. We carried out a comprehensive analysis of gene-expression profiles using expressed sequence tags (ESTs) to identify genes overexpressed in the human adult heart. The initial set of genes expressed in the heart was constructed by clustering and assembling ESTs from heart cDNA libraries. Expression profiles were then generated for each gene by counting their cognate ESTs in all libraries. Differential expression was assessed by applying a previously published statistical procedure to these profiles.

Results

We identified 35 cardiac-specific genes overexpressed in the heart, some of which displayed si

SUBMITTER: Megy K 

PROVIDER: S-EPMC151176 | biostudies-literature | 2002

REPOSITORIES: biostudies-literature