Towards reconstruction of gene networks from expression data by supervised learning.

ABSTRACT: BACKGROUND:Microarray experiments are generating datasets that can help in reconstructing gene networks. One of the most important problems in network reconstruction is finding, for each gene in the network, which genes can affect it and how. We use a supervised learning approach to address this question by building decision-tree-related classifiers, which predict gene expression from the expression data of other genes. RESULTS:We present algorithms that work for continuous expression levels and do not require a priori discretization. We apply our method to publicly available data for the budding yeast cell cycle. The obtained classifiers can be presented as simple rules defining gene interrelations. In most cases the extracted rules confirm the existing knowledge about cell-cycle gene exp

SUBMITTER: Soinov LA 

PROVIDER: S-EPMC151290 | biostudies-literature | 2003

REPOSITORIES: biostudies-literature