Genome-wide analysis of microsatellite repeats in humans: their abundance and density in specific genomic regions.

ABSTRACT: BACKGROUND:Simple sequence repeats (SSRs) are found in most organisms, and occupy about 3% of the human genome. Although it is becoming clear that such repeats are important in genomic organization and function and may be associated with disease conditions, their systematic analysis has not been reported. This is the first report examining the distribution and density of simple sequence repeats (1-6 base-pairs (bp)) in the entire human genome. RESULTS:The densities of SSRs across the human chromosomes were found to be relatively uniform. However, the overall density of SSR was found to be high in chromosome 19. Triplets and hexamers were more predominant in exonic regions compared to intronic and intergenic regions, except for chromosome Y. Comparison of densities of various SSRs revealed

SUBMITTER: Subramanian S 

PROVIDER: S-EPMC151303 | biostudies-literature | 2003

REPOSITORIES: biostudies-literature