Sexually dimorphic gene expression that overlaps maturation of type II pneumonocytes in fetal mouse lungs.

ABSTRACT:

Background

In human, respiratory distress of the neonates, which occurs in prematurity, is prevalent in male. Late in gestation, maturation of type II pneumonocytes, and consequently the surge of surfactant synthesis are delayed in male fetuses compared with female fetuses. Although the presence of higher levels of androgens in male fetuses is thought to explain this sex difference, the identity of genes involved in lung maturation that are differentially modulated according to fetal sex is unknown. We have studied the sex difference in developing mouse lung by gene profiling during a three-day gestational window preceding and including the emergence of mature PTII cells (the surge of surfactant synthesis in the mouse occurs on GD 17.5).

Methods

Total RNA was extracted from

SUBMITTER: Simard M 

PROVIDER: S-EPMC1513230 | biostudies-literature | 2006 May

REPOSITORIES: biostudies-literature