Adherence with isoniazid for prevention of tuberculosis among HIV-infected adults in South Africa.

ABSTRACT:

Background

Tuberculosis (TB) is the most common opportunistic infection in HIV-infected adults in developing countries. Isoniazid (INH) is recommended for treatment of latent TB infection, however non-adherence is common. The purpose of this study was to apply in-house prepared isoniazid (INH) urine test strips in a clinical setting, and identify predictors of positive test results in an adherence questionnaire in HIV-infected adults taking INH for prevention of TB.

Methods

Cross-sectional study of adherence using a questionnaire and urine test strips for detection of INH metabolites at two hospitals in Pietermaritzburg, South Africa. Participants were aged at least 18 years, HIV positive, and receiving INH for prevention of tuberculosis disease. Univariate and multivariate

SUBMITTER: Szakacs TA 

PROVIDER: S-EPMC1513236 | biostudies-literature | 2006 Jun

REPOSITORIES: biostudies-literature