Transcriptional profiling of aging in human muscle reveals a common aging signature.

ABSTRACT: We analyzed expression of 81 normal muscle samples from humans of varying ages, and have identified a molecular profile for aging consisting of 250 age-regulated genes. This molecular profile correlates not only with chronological age but also with a measure of physiological age. We compared the transcriptional profile of muscle aging to previous transcriptional profiles of aging in the kidney and the brain, and found a common signature for aging in these diverse human tissues. The common aging signature consists of six genetic pathways; four pathways increase expression with age (genes in the extracellular matrix, genes involved in cell growth, genes encoding factors involved in complement activation, and genes encoding components of the cytosolic ribosome), while two pathways decrease ex

SUBMITTER: Zahn JM 

PROVIDER: S-EPMC1513263 | biostudies-literature | 2006 Jul

REPOSITORIES: biostudies-literature