Ontology highlight
ABSTRACT:
SUBMITTER: Shen LN
PROVIDER: S-EPMC1513277 | biostudies-literature | 2006 Jul
REPOSITORIES: biostudies-literature
Shen Lin Nan LN Dong Changjiang C Liu Huanting H Naismith James H JH Hay Ronald T RT
The Biochemical journal 20060701 2
The SUMO (small ubiquitin-like modifier)-specific protease SENP1 (sentrin-specific protease 1) can process the three forms of SUMO to their mature forms and deconjugate SUMO from modified substrates. It has been demonstrated previously that SENP1 processed SUMO-1 more efficiently than SUMO-2, but displayed little difference in its ability to deconjugate the different SUMO paralogues from modified substrates. To determine the basis for this substrate specificity, we have determined the crystal st ...[more]